杨莹

女，教授，雷竞技平台同济医学院雷竞技ray官网。研究方向为阿尔茨海默病的分子、神经环路机制及其干预策略。主持国家自然科学基金（面上及青年项目）、国家重大科技计划培育项目、教育部留学回国人员科研启动基金、湖北省卫计委青年人才项目等；作为骨干成员参与多项国家自然科学基金重点项目研究。以共同第一作者或共同通讯作者在Neuron、Nature Communications、Signal transduction and targeted therapy、Military medical research、Molecular neurodegeneration、Clinical and translational medicine等国际权威期刊发表学术论文。

近5年主持的国家自然科学基金项目：

（1）国家自然科学基金委员会,面上项目, 82371436, dvCA1^Calb1+神经元高易感性及其在阿尔茨海默病样情景记忆损伤中的作用和分子/环路调节机制，2024-01-01至2027-12-31，49万元,在研,主持

（2）国家自然科学基金委员会,面上项目, 82071219,腹侧海马背侧部tau异常聚集及其在阿尔茨海默病记忆损伤中的作用及机制研究, 2021-01-01至2024-12-31, 55万元,结题,主持

近5年代表性论文(#第一作者；*通讯作者)

1. Huiyang Lei #, Jingru Lv #, Fuqiang Zhang #, Linyu Wei, Kun Shi, Jiale Liu, Ting He, Rui Xiong, Fei Sun, Tongkai Zhong, Jingqi Zhao, Dan Ke, Qun Wang, Peiran Jiang, Ai-Min Bao, Jian-Zhi Wang*,Ying Yang*.Improving vulnerable Calbindin1- neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory.Transl Neurodegener. 2025 Mar 4;14(1):12.

2. Xin Wang #, Qian Liu #, Hai-Tao Yu #, Jia-Zhao Xie, Jun-Ning Zhao, Zhi-Ting Fang, Min Qu, Yao Zhang*,Ying Yang*, Jian-Zhi Wang*.A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology.Signal Transduct Target Ther. 2024 Apr 29;9(1):105.

3. Hui-Yang Lei #, Gui-Lin Pi #, Ting He #, Rui Xiong, Jing-Ru Lv, Jia-Le Liu, Dong-Qin Wu, Meng-Zhu Li, Kun Shi, Shi-Hong Li, Na-Na Yu, Yang Gao, Hui-Ling Yu, Lin-Yu Wei, Xin Wang, Qiu-Zhi Zhou, Pei-Lin Zou, Jia-Yang Zhou, Ying-Zhou Liu, Nai-Ting Shen, Jie Yang, Dan Ke, Qun Wang, Gong-Ping Liu, Xi-Fei Yang, Jian-Zhi Wang*,Ying Yang*.Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss.Mil Med Res. 2024 Mar 11;11(1):16.

4. Dongqin Wu #, Nana Yu #, Yang Gao #, Rui Xiong, Luping Liu, Huiyang Lei, Sen Jin, Jiale Liu, Yingzhou Liu, Jiazhao Xie, Enjie Liu, Qiuzhi Zhou, Yanchao Liu, Shihong Li, Linyu Wei, Jingru Lv, Huilin Yu, Wenbo Zeng, Qiang Zhou, Fuqiang Xu, Min-Hua Luo 5, Yao Zhang*,Ying Yang*, Jian-Zhi Wang*.Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation.Mol Neurodegener. 2023 Apr 14;18(1):23.

5. Huiling Yu, Liping Chen, Huiyang Lei, Guilin Pi, Rui Xiong, Tao Jiang, Dongqin Wu, Fei Sun, Yang Gao, Yuanhao Li, Wenju Peng, Bingyu Huang, Guoda Song, Xin Wang, Jingru Lv, Zetao Jin, Dan Ke,Ying Yang*, Jian-Zhi Wang*.Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours.Nat Commun. 2022 Sep 17;13(1):5462.

6. Jia-Zhao Xie#, Yao Zhang#, Shi-Hong Li, Hui Wei, Hui-Ling Yu, Qiu-Zhi Zhou, Lin-Yu Wei, Dan Ke, Qun Wang,Ying Yang*, Jian-Zhi Wang*.P301S-hTau acetylates KEAP1 to trigger synaptic toxicity via inhibiting NRF2/ARE pathway: A novel mechanism underlying hTau-induced synaptic toxicities.Clin Transl Med. 2022 Aug;12(8):e1003.

7. Dongqin Wu, Di Gao, Haitao Yu, Guilin Pi, Rui Xiong, Huiyang Lei, Xin Wang, Enjie Liu, Jinwang Ye, Huilin Yu, Yang Gao, Ting He, Tao Jiang, Fei Sun, Jingfen Su, Guoda Song, Wenju Peng,Ying Yang*, Jian-Zhi Wang*.Medial septum tau accumulation induces spatial memory deficit via disrupting medial septum-hippocampus cholinergic pathway.Clin Transl Med. 2021 Jun;11(6):e428.

8. Guilin Pi#, Di Gao#, Dongqin Wu, Yali Wang, Huiyang Lei, Wenbo Zeng, Yang Gao, Huiling Yu, Rui Xiong, Tao Jiang, Shihong Li, Xin Wang, Jing Guo, Si Zhang, Taoyuan Yin, Ting He, Dan Ke, Ruining Li, Honglian Li, Gongping Liu, Xifei Yang, Min-Hua Luo, Xiaohui Zhang,Ying Yang*, Jian-Zhi Wang*.Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect.Nat Commun. 2020 Jan 10;11(1):183.