雷家慧，医学博士，病原生物学系教授，哈佛大学访问学者。

主要研究方向为病原感染免疫学、虫源性分子对免疫性疾病的调控作用和应用以及肝纤维化的免疫调控机制。主持国家和省部课题8项，参与科技部国家重点研发项目、国家自然基金、973和863基金等10余项。发表中英文论文 50 余篇，论文先后获得武汉市优秀科技论文奖二等奖和三等奖。先后担任人民卫生出版社公共卫生与预防医学“101 计划”《 病原生物与免疫学》、全国高等医学教育临床医学专业课程思政案例库《人体寄生虫学》、《临床寄生虫病学》第二版和《人体寄生虫学》第八版电子教材编委。担任中华医学会热带病与寄生虫学分会青年委员、中华预防医学会医学寄生虫学分会青年委员、湖北省热带病与寄生虫学学会主任委员、湖北省预防医学会寄生虫学专业委员会常务委员、湖北省血吸虫病咨询委员会委员和武汉市预防医学会寄生虫学委员会副主任委员。兼任《中华地方病学杂志》、《Zoonoses》和《热带病与寄生虫学》杂志编委。

联系方式：leijiahui@hust.edu.cn

近5年主要发表文章（#第一作者；*通讯作者）：

1. Gu H#, Xie M#, Zhao S, Luo X, Huang Y, Yang L, Guan F, Lei J*, Liu C*. DOCK8 gene mutation alters cell subsets, BCR signaling, and cell metabolism in B cells. Cell Death Dis 2024; 15(11):871. doi:10.1038/s41419-024-07180-w.

2. Zhu F#, Zheng W#, Gong Y, Zhang J, Yu Y, Zhang J, Liu M, Guan F*, Lei J*. Trichinella spiralis Infection Inhibits the Efficacy of RBD Protein of SARS-CoV-2 Vaccination via Regulating Humoral and Cellular Immunity. Vaccines (Basel). 2024 Jun 30;12(7):729. doi: 10.3390/vaccines12070729.

3. Zhu H#, Deng W, Guan F, Lei J*. Development of the WeChat Public Account I Love Parasitology and its Preliminary Application in the Teaching of Human Parasitology. J Med Educ Curric Dev. 2024 May 26:11:23821205241255224. doi: 10.1177/23821205241255224.

4. Lei J#, Feng Y, Zheng W, Khamis M, Zhang J, Hou X, Guan F*. Type I/II Immune Balance Contributes to the Protective Effect of AIF-1 on Hepatic Immunopathology Induced by Schistosoma japonicum in a Transgenic Mouse Model. Inflammation. 2024 Mar 30. doi: 10.1007/s10753-024-02010-9.

5. Guan F#, Luo X, Liu J, Huang Y, Liu Q, Chang J, Fang G, Kang D, Gu H, Luo L, Yang L, Lin Z, Gao X, Liu C, Lei J*. GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells. iScience. 2023 Jul 16;26(8):107341. doi: 10.1016/j.isci.2023.107341.

6. Hou X#, Zhu F, Zheng W, Jacques ML, Huang J, Guan F, Lei J*. Protective effect of Schistosoma japonicum eggs on TNBS-induced colitis is associated with regulating Treg/Th17 balance and reprogramming glycolipid metabolism in mice. Front Cell Infect Microbiol. 2022 Oct 11:12:1028899. doi: 10.3389/fcimb.2022.1028899.

7. Zhu F#, Liu W, Liu T, Shi L, Zheng W, Guan F, Lei J*. A New Role for Old Friends: Effects of Helminth Infections on Vaccine Efficacy. Pathogens. 2022 Oct 8;11(10):1163. doi: 10.3390/pathogens11101163.

8. Lei JH#, Guan F, Zhu HG, Liu WQ*. Online education in human parasitology during the COVID-19 pandemic in Wuhan: Our experiences, challenges, and perspectives. Zoonoses, 2022, 2(1): 1.

9. Bai Y#, Guan F#, Zhu F, Jiang C, Zheng F, Liu W, Lei J*. IL-33/ST2 Axis Deficiency Exacerbates Hepatic Pathology by Regulating Treg and Th17 Cells in Murine Schistosomiasis Japonica. J Inflamm Res. 2021 Nov 15:14:5981-5998. doi: 10.2147/JIR.S336404.

10. Xin C#, Lei J#, Wang Q, Yin Y, Yang X, Moran Guerrero JA, Sabbisetti V, Sun X, Vaidya VS*, Bonventre JV*. Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease. iScience. 2021 Sep 29;24(10):103193. doi: 10.1016/j.isci.2021.103193.

11. Guan F#, Jiang W, Bai Y, Hou X, Jiang C, Zhang C, Jacques ML, Liu W, Lei JH *. Purinergic P2X7 Receptor Mediates the Elimination of Trichinella spiralis by Activating NF-κB/NLRP3/IL-1β Pathway in Macrophages. Infect Immun. 2021 Apr 16;89(5):e00683-20. doi: 10.1128/IAI.00683-20.

12. Guan F#, Zhang C, Jiang C, Jacques ML, Bai Y, Lu S, Liu W, Lei JH*. ApoE deficiency promotes hepatic pathology by aggravating Th17/Treg imbalance in murine schistosomiasis japonica. Parasite Immunol. 2020 Dec;42(12):e12785. doi: 10.1111/pim.12785.

13. Jacques M#, Mahamane Salissou M, Kaswiyi L, Guan F, Lei JH*. Co-infection of malaria and HIV infection in severely undernourished children in the Democratic Republic of the Congo: a cross-sectional study. Parasitology. 2020 Feb;147(2):248-253. doi: 10.1017/S0031182019001513.

14. Langston PK#, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei JH, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T*. Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. Nat Immunol. 2019 Sep;20(9):1186-1195. doi: 10.1038/s41590-019-0453-7.